Speech symptoms in parkinson`s disease base upon reduced sensorimotor integration

In Tribute: Farshid Mohammadi, PT, PhD, Proprioception and Sensorimotor Integration in Parkinson’s Disease

Altered sensorimotor integration in Parkinson's disease.

Transcranial magnetic stimulation (TMS) was used to investigate sensorimotor integration in the upper limb of 10 patients with Parkinson's disease and 10 age-matched controls. Non-conditioned and subthreshold conditioned (2 ms interstimulus interval) responses were recorded in the flexor and extensor carpi radialis muscles (FCR and ECR) of the more impaired (non-dominant) limb. Stimuli were del...

Sensorimotor adaptation of speech in Parkinson's disease.

The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on li...

Lexical-perceptual integration influences sensorimotor adaptation in speech

A combination of lexical bias and altered auditory feedback was used to investigate the influence of higher-order linguistic knowledge on the perceptual aspects of speech motor control. Subjects produced monosyllabic real words or pseudo-words containing the vowel [ε] (as in "head") under conditions of altered auditory feedback involving a decrease in vowel first formant (F1) frequency. This ma...

Sensorimotor Integration in Speech Processing: Computational Basis and Neural Organization

Sensorimotor integration is an active domain of speech research and is characterized by two main ideas, that the auditory system is critically involved in speech production and that the motor system is critically involved in speech perception. Despite the complementarity of these ideas, there is little crosstalk between these literatures. We propose an integrative model of the speech-related "d...